You are a biomedical engineer working in the Research and Development Division of a company in the cardiovascular prostheses field. Your project is to design a blood compatible material for vascular prostheses.
a. What characteristics should this material have?
b. The implant must be designed to last for a minimum of 3 years in-vivo. There are 2 major mechanisms of chemical degradation of polymers in-vivo. Describe each of these mechanisms. Given the following polymers, indicate whether they are susceptible to hydrolysis, oxidation, both or neither of these processes.
Poly(carbonate urethane) Poly(ether urethane)
Poly(ethylene terephthalate) Polyethylene (linear)
Polytetrafluoroethylene
c. Choose one of these materials for your new heart valve material. Justify your choice.
d. Discuss the factors that influence cell adhesion to biomaterials surfaces.
e. How could you modify the surface of this material to improve its haemocompatibility?
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